JOINT RESEARCH


I
MPROVING SAMPLE PREPARATION TECHNOLOGIES FOR NMR STUDIES

One single Joint Research Activity is planned within EAST-NMR with the main objective of developing procedures for the production of membrane protein samples for NMR spectroscopy. The JRA will aspire to comprehensive, uniform documentation to reach this goal. A large number of biology groups in Europe will benefit from the results of the JRA for their NMR spectroscopic investigations. The offering of optimised procedures for the production of membrane proteins assures an efficient use of the participating NMR research infrastructures from the very early stages of sample preparation and contributes to Good Laboratory Practices (GLP).

In addition, structure determination of molecular complexes and increasingly large molecules requires the establishment of robust technologies that provide novel long-range structure restraints including paramagnetic tagging and novel alignment media. This means improvements in both the service offered by the RIs to their users in terms of quality and quantity, and also in the joint use of the RIs.

The Eastern European Partners will team up with the Centers in West Europe and participate in the JRA by secondment of personell to later establish key technology at their centers.

/